Chitta Das
Professor

AFFILIATIONS: Chemistry
OFFICE: BRWN 3131
LAB: xxx
PHONE: 765-494-6328
EMAIL: cdas@purdue.edu

Research

The broad research interest of my group centers around protein ubiquitination and its relationship with bacterial pathogens. Specifically, understanding mechanism of action of deubiquitinases (DUBs) and ubiquitin modifying enzymes of both prokaryotic and eukaryotic origin. Using crystallography, biochemical and biophysical data we wish to unravel mechanism of action of these enzymes, including regulation of catalytic activity and substrate selection. The fact that viruses and bacteria manipulate our ubiquitination pathways has been known for at least two decades, with a number of well characterized examples of pathogens using enzymes or substrate adaptors to co-opt our ubiquitination pathways.

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