John Tesmer
John Tesmer
Walther Distinguished Professor in Cancer Structural Biology
AFFILIATIONS: Biological Sciences
OFFICE: HOCK 329
LAB: xxx
PHONE: 765-494-1807
EMAIL: cbp@purdue.edu
Research
My lab studies the molecular basis of G protein-coupled receptor (GPCR)-mediated signal transduction using small-angle X-ray scattering, X-ray crystallography, and single particle cryo-electron microscopy (cryo-EM). By determining structures of signaling proteins alone and in complex with their various targets, we provide important insights into the molecular basis of signal transduction, explain how diseases result from dysfunctional regulation, and leverage this information to develop new therapeutic approaches.
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