Ramaswamy Subramanian
Rams Subramanian
Professor and Director of Bindley Biosciences Center
AFFILIATIONS: Biological Sciences
OFFICE: DLR 433
LAB: xxx
PHONE: 765-496-2235
EMAIL: subram68@purdue.edu
Research
Dimethyl formamidase is not a naturally occurring compound. It was first synthesized in 1853. It is highly stable, and dissolves both polar and non-polar compounds. It is hence one of the most used solvents in several chemical industry. Its properties that make it the preferred solvent also makes it difficult to break down and is also the reason for its toxicity. It is broken down at high temperatures and harsh conditions. In a short while, a few species of bacteria have developed the ability break it down. The first step is a halo-stable enzyme Dimethyl Formamidase, that has a new fold and a rather unique active site. In the talk, I will present the structure (determined by EM and X-ray)- function studies on this enzyme.
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